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1

Natural-Product-Like Spiroketals and Fused Bicyclic Acetals as Potential Therapeutic Agents for B-Cell Chronic Lymphocytic Leukaemia

Lech-Gustav Milroy, Giovanna Zinzalla, François Loiseau, Zizheng Qian, Giuseppe Prencipe, Chris Pepper, Chris Fegan, Steven V. Ley

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 535 KB

english, 2008

2

The effect of immunoglobulin VH gene mutation status and other prognostic factors on the incidence of major infections in patients with chronic lymphocytic leukemia

Sebastian Francis, Mamatha Karanth, Guy Pratt, Jane Starczynski, Laura Hooper, Chris Fegan, Chris Pepper, David Valcarcel, Donald W. Milligan, Julio Delgado

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 256 KB

english, 2006

3

Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia

Rebecca L. Auer, Jane Starczynski, Suzanne McElwaine, Francesco Bertoni, Adrian C. Newland, Chris D. Fegan, Finbarr E. Cotter

Journal:

Genes, Chromosomes and Cancer

Année:

2005

Langue:

english

Fichier:

PDF, 158 KB

english, 2005

4

Two germ line polymorphisms of the tumour suppressor gene p53 may influence the biology of chronic lymphocytic leukaemia

Geothy Kochethu, Julio Delgado, Chris Pepper, Jane Starczynski, Laura Hooper, Satish Krishnan, Christopher Fegan, Guy Pratt

Journal:

Leukemia Research

Année:

2006

Langue:

english

Fichier:

PDF, 136 KB

english, 2006

5

Molecular detection of Gluconacetobacter sacchari associated with the pink sugarcane mealybug Saccharicoccus sacchari (Cockerell) and the sugarcane leaf sheath microenvironment by FISH and PCR

Ingrid H. Franke, Mark Fegan, Chris Hayward, Graham Leonard, Lindsay I. Sly

Journal:

FEMS Microbiology Ecology

Année:

2000

Langue:

english

Fichier:

PDF, 6.61 MB

english, 2000

6

Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia

Chris Pepper, Alun Thomas, Terry Hoy, Chris Fegan, Paul Bentley

Journal:

British Journal of Haematology

Année:

2001

Langue:

english

Fichier:

PDF, 384 KB

english, 2001

7

Allele and haplotype frequency at human leucocyte antigen class I/II and immunomodulatory cytokine loci in patients with myelodysplasia and acute myeloid leukaemia: in search of an autoimmune aetiology

Duncan Gowans, Alan O'Sullivan, Sara Rollinson, Phillipa Roddam, Mike Groves, Chris Fegan, Gareth Morgan, David Bowen

Journal:

British Journal of Haematology

Année:

2002

Langue:

english

Fichier:

PDF, 69 KB

english, 2002

8

The P2X7 receptor gene polymorphism 1513 A→C has no effect on clinical prognostic markers, in vitro sensitivity to fludarabine, Bcl-2 family protein expression or survival in B-cell chronic lymphocytic leukaemia

Jane Starczynski, Chris Pepper, Guy Pratt, Laura Hooper, Alun Thomas, Terry Hoy, Donald Milligan, Paul Bentley, Christopher Fegan

Journal:

British Journal of Haematology

Année:

2003

Langue:

english

Fichier:

PDF, 245 KB

english, 2003

9

The safety and effectiveness of a nurse-led anticoagulant service

Carole A. Connor, Chris C. Wright, Christopher D. Fegan

Journal:

Journal of Advanced Nursing

Année:

2002

Langue:

english

Fichier:

PDF, 134 KB

english, 2002

10

Highly purified CD38+ sub-populations show no evidence of preferential clonal evolution despite having increased proliferative activity when compared with CD38− sub-populations derived from the same chronic lymphocytic leukaemia patient

Thet Thet Lin, Saman Hewamana, Rachel Ward, Hannah Taylor, Tammy Payne, Guy Pratt, Duncan Baird, Chris Fegan, Chris Pepper

Journal:

British Journal of Haematology

Année:

2008

Langue:

english

Fichier:

PDF, 417 KB

english, 2008

11

Abnormal serum free light chain ratios are associated with poor survival and may reflect biological subgroups in patients with chronic lymphocytic leukaemia

Guy Pratt, Stephen Harding, Roger Holder, Chris Fegan, Chris Pepper, David Oscier, Anne Gardiner, Arthur R. Bradwell, Graham Mead

Journal:

British Journal of Haematology

Année:

2009

Langue:

english

Fichier:

PDF, 246 KB

english, 2009

12

Beta2-microglobulin is a better predictor of treatment-free survival in patients with chronic lymphocytic leukaemia if adjusted according to glomerular filtration rate

Julio Delgado, Guy Pratt, Neil Phillips, Javier Briones, Chris Fegan, Josep Nomdedeu, Chris Pepper, Anna Aventin, Ramon Ayats, Salut Brunet, Rodrigo Martino, David Valcarcel, Donald Milligan, Jorge Si

Journal:

British Journal of Haematology

Année:

2009

Langue:

english

Fichier:

PDF, 74 KB

english, 2009

13

A polymorphism in the 3′ UTR of IRF4 linked to susceptibility and pathogenesis in chronic lymphocytic leukaemia and Hodgkin lymphoma has limited impact in multiple myeloma

Guy Pratt, James A. L. Fenton, David Allsup, Chris Fegan, Gareth J. Morgan, Graham Jackson, Nicola J. Sunter, Andrew G. Hall, Julie A.E. Irving, James M. Allan

Journal:

British Journal of Haematology

Année:

2010

Langue:

english

Fichier:

PDF, 69 KB

english, 2010

14

Molecular detection of Gluconacetobacter sacchari associated with the pink sugarcane mealybug Saccharicoccus sacchari (Cockerell) and the sugarcane leaf sheath microenvironment by FISH and PCR

Ingrid H. Franke, Mark Fegan, Chris Hayward, Graham Leonard, Lindsay I. Sly

Journal:

FEMS Microbiology Ecology

Année:

2000

Langue:

english

Fichier:

PDF, 6.60 MB

english, 2000

15

Partial Sequencing of the hrpB and Endoglucanase Genes Confirms and Expands the Known Diversity within the Ralstonia solanacearum Species Complex

Stephane Poussier, Philippe Prior, Jacques Luisetti, Chris Hayward, Mark Fegan

Journal:

Systematic and Applied Microbiology

Année:

2000

Langue:

english

Fichier:

PDF, 3.39 MB

english, 2000

16

Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells

Emma Hamilton, Laurence Pearce, Liam Morgan, Sophie Robinson, Vicki Ware, Paul Brennan, N. Shaun B. Thomas, Deborah Yallop, Stephen Devereux, Chris Fegan, Andrea G. S. Buggins, Chris Pepper

Journal:

British Journal of Haematology

Année:

2012

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2012

17

2.42 Mimicking the Tumor Microenvironment: Three Different Co-culture Systems Induce a Similar Phenotype but Different Proliferative Signals in Primary Chronic Lymphocytic Leukemia Cells

Emma Hamilton, Laurence Pearce, Liam Morgan, Paul Brennan, N. Shaun B. Thomas, Deborah Yallop, Chris Fegan, Stephen Devereux, Andrea G.S. Buggins, Chris Pepper

Journal:

Clinical Lymphoma Myeloma and Leukemia

Année:

2011

Langue:

english

Fichier:

PDF, 84 KB

english, 2011

18

4.24 Telomere Dysfunction is the Critical Determinant of Clinical Outcome in CLL

Thet Thet Lin, Guy Pratt, Robert Hills, Bethan Britt-Compton, Chris Fegan, Duncan M. Baird, Chris Pepper

Journal:

Clinical Lymphoma Myeloma and Leukemia

Année:

2011

Langue:

english

Fichier:

PDF, 91 KB

english, 2011

19

4.1 Elevated Serum Free Light Chains Independently Identify a Poor Risk Group of Stage A CLL Patients

Guy Pratt, Philip J. Young, Chris Pepper, Chris Fegan, Anne Gardiner, David Oscier, Graham Mead, Stephen Harding

Journal:

Clinical Lymphoma Myeloma and Leukemia

Année:

2011

Langue:

english

Fichier:

PDF, 80 KB

english, 2011

20

5.46 NCRN CLL207 Study of Alemtuzumab Consolidation in Chronic Lymphocytic Leukaemia: Response Assessment Follow-up and Pharmacokinetic studies (on Behalf of the NCRI CLL Trials Sub-Group)

Abraham M. Varghese, Dena Cohen, Christopher F. Pocock, Andy Rawstron, Walter M. Gregory, Alex Smith, Emma Skinner, Anne Critchley, Donald Milligan, Claire E. Dearden, Helen McCarthy, Chris Fegan, Geo

Journal:

Clinical Lymphoma Myeloma and Leukemia

Année:

2011

Langue:

english

Fichier:

PDF, 90 KB

english, 2011

21

The effect of supervised exercise and cilostazol on coagulation and fibrinolysis in intermittent claudication: A randomized controlled trial

Hobbs, Simon D., Marshall, Tim, Fegan, Chris, Adam, Donald J., Bradbury, Andrew W.

Journal:

Journal of Vascular Surgery

Année:

2007

Langue:

english

Fichier:

PDF, 98 KB

english, 2007

22

The role of tissue factor in patients undergoing open repair of ruptured and nonruptured abdominal aortic aneurysms

Hobbs, Simon D., Haggart, Paul, Fegan, Chris, Bradbury, Andrew W., Adam, Donald J.

Journal:

Journal of Vascular Surgery

Année:

2007

Langue:

english

Fichier:

PDF, 178 KB

english, 2007

23

The constitutive procoagulant and hypofibrinolytic state in patients with intermittent claudication due to infrainguinal disease significantly improves with percutaneous transluminal balloon angioplasty

Hobbs, Simon D., Marshall, Tim, Fegan, Chris, Adam, Donald J., Bradbury, Andrew W.

Journal:

Journal of Vascular Surgery

Année:

2006

Langue:

english

Fichier:

PDF, 132 KB

english, 2006

24

The P2X7 receptor gene polymorphism 1513 A→C has no effect on clinical prognostic markers and survival in multiple myeloma

Paneesha, Shankaranarayana, Starczynski, Jane, Pepper, Chris, Delgado, Julio, Hooper, Laura, Fegan, Christopher, Pratt, Guy

Journal:

Leukemia and Lymphoma

Année:

2006

Langue:

english

Fichier:

PDF, 228 KB

english, 2006

25

Flavopiridol Induces Apoptosis in B-cell Chronic Lymphocytic Leukaemia Cells Through a p38 and ERK MAP Kinase-dependent Mechanism

Pepper, Chris, Thomas, Alun, Fegan, Chris, Hoy, Terry, Bentley, Paul

Journal:

Leukemia and Lymphoma

Année:

2003

Langue:

english

Fichier:

PDF, 179 KB

english, 2003

26

Telomere analysis to predict chronic lymphocytic leukemia outcome: a STELA test to change clinical practice?

Pepper, Chris, Baird, Duncan, Fegan, Chris

Journal:

Expert Review of Hematology

Année:

2014

Langue:

english

Fichier:

PDF, 378 KB

english, 2014

27

Understanding cancer cell survival is key to patient survival

Fegan, Chris, Pepper, Chris

Journal:

The Lancet Oncology

Année:

2015

Langue:

english

Fichier:

PDF, 289 KB

english, 2015

28

CD8 + T-cell recognition of a synthetic epitope formed by t -butyl modification

Reid, Reiss A., Redman, James E., Rizkallah, Pierre, Fegan, Chris, Pepper, Chris, Man, Stephen

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 741 KB

english, 2014

29

Retinoid-induced apoptosis in B-cell chronic lymphocytic leukaemia cells is mediated through caspase-3 activation and is independent of p53, the retinoic acid receptor, and differentiation

Pepper, Chris, Ali, Khalida, Thomas, Alun, Hoy, Terry, Fegan, Chris, Chowdary, Pratima, Kell, Jonathan, Bentley, Paul

Journal:

European Journal of Haematology

Année:

2002

Langue:

english

Fichier:

PDF, 336 KB

english, 2002

30

NF-κB as a prognostic marker and therapeutic target in chronic lymphocytic leukemia

Pepper, Chris, Hewamana, Saman, Brennan, Paul, Fegan, Chris

Journal:

Future Oncology

Année:

2009

Langue:

english

Fichier:

PDF, 3.00 MB

english, 2009

31

Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models

Ndungu, Francis Maina, Marsh, Kevin, Fegan, Gregory, Wambua, Juliana, Nyangweso, George, Ogada, Edna, Mwangi, Tabitha, Nyundo, Chris, Macharia, Alex, Uyoga, Sophie, Williams, Thomas N, Bejon, Philip

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.40 MB

english, 2015

32

Co-operative Membrane Disruption Between Cell-penetrating Peptide and Cargo: Implications for the Therapeutic Use of the Bcl-2 Converter Peptide D-NuBCP-9-r8

Watkins, Catherine L, Sayers, Edward J, Allender, Chris, Barrow, David, Fegan, Christopher, Brennan, Paul, Jones, Arwyn T

Journal:

Molecular Therapy

Année:

2011

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2011

33

Leukemic and Non-Leukemic Lymphocytes from Patients with Li Fraumeni Syndrome Demonstrate Loss of p53 Function, Bcl-2 Family Dysregulation and Intrinsic Resistance to Conventional Chemotherapeutic Drugs But Not Flavopiridol

Pepper, Chris, Thomas, Alun, Hoy, Terry, Tighe, Jane, Culligan, Dominic, Fegan, Chris, Bentley, Paul

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 490 KB

english, 2003

34

Telomere length is a critical determinant for survival in multiple myeloma

Hyatt, Sam, Jones, Rhiannon E., Heppel, Nicole H., Grimstead, Julia W., Fegan, Chris, Jackson, Graham H., Hills, Robert, Allan, James M., Pratt, Guy, Pepper, Chris, Baird, Duncan M.

Journal:

British Journal of Haematology

Année:

2017

Langue:

english

Fichier:

PDF, 486 KB

english, 2017

35

A multi-centre phase I trial of the PARP inhibitor olaparib in patients with relapsed chronic lymphocytic leukaemia, T-prolymphocytic leukaemia or mantle cell lymphoma

Pratt, Guy, Yap, Christina, Oldreive, Ceri, Slade, Daniel, Bishop, Rebecca, Griffiths, Mike, Dyer, Martin J. S., Fegan, Chris, Oscier, David, Pettitt, Andrew, Matutes, Estella, Devereux, Stephen, Alls

Journal:

British Journal of Haematology

Année:

2017

Langue:

english

Fichier:

PDF, 94 KB

english, 2017

36

Estimating Individual Exposure to Malaria Using Local Prevalence of Malaria Infection in the Field

Olotu, Ally, Fegan, Gregory, Wambua, Juliana, Nyangweso, George, Ogada, Edna, Drakeley, Chris, Marsh, Kevin, Bejon, Philip, Mueller, Ivo

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 211 KB

english, 2012

37

Telomere length predicts for outcome to FCR chemotherapy in CLL

Norris, Kevin, Hillmen, Peter, Rawstron, Andrew, Hills, Robert, Baird, Duncan M., Fegan, Christopher D., Pepper, Chris

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 840 KB

english, 2019

38

Telomere fusions associate with coding sequence and copy number alterations in CLL

Escudero, Laura, Cleal, Kez, Ashelford, Kevin, Fegan, Chris, Pepper, Chris, Liddiard, Kate, Baird, Duncan M.

Journal:

Année:

2019

Fichier:

PDF, 1.68 MB

2019

39

A CD21 low phenotype, with no evidence of autoantibodies to complement proteins, is consistent with a poor prognosis in CLL

Nichols, Eva-Maria, Jones, Rachel, Watson, Rachael, Pepper, Chris J., Fegan, Chris, Marchbank, Kevin J.

Journal:

Année:

2015

Fichier:

PDF, 1.70 MB

2015

40

Is venetoclax a new wonder drug in CLL?

Fegan, Chris, Pepper, Chris

Journal:

British Journal of Haematology

Année:

2019

Fichier:

PDF, 112 KB

2019

41

Telomere fusions associate with coding sequence and copy number alterations in CLL

Escudero, Laura, Cleal, Kez, Ashelford, Kevin, Fegan, Chris, Pepper, Chris, Liddiard, Kate, Baird, Duncan M.

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 1.68 MB

english, 2019

42

A CD21 low phenotype, with no evidence of autoantibodies to complement proteins, is consistent with a poor prognosis in CLL

Nichols, Eva-Maria, Jones, Rachel, Watson, Rachael, Pepper, Chris J., Fegan, Chris, Marchbank, Kevin J.

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.70 MB

english, 2015

43

Clinical utility of telomere length measurements in cancer

Pepper, Chris, Norris, Kevin, Fegan, Christopher

Journal:

Current Opinion in Genetics & Development

Année:

2020

Fichier:

PDF, 292 KB

2020

44

Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-ÎºB activity and synergise with bortezomib and ibrutinib in hematological cancers

Lewis, Thomas, Corcoran, David B., Thurston, David E., Giles, Peter J., Ashelford, Kevin, Walsby, Elisabeth J., Fegan, Christopher D., Pepper, Andrea G.S., Rahman, Khondaker Miraz, Pepper, Chris

Journal:

Année:

2020

Fichier:

PDF, 4.65 MB

2020